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A novel mitophagy activator, UMI-77, alleviated apoptosis of RTEC and interstitial inflammation by activating mitophagy, inhibiting TGF-1/Smad-mediated MFB activation and hindering renal fibrosis ( 4.2.2.2 Hormone receptor agonists/antagonists Finerenone, a novel mineralocorticoid receptor antagonist, ameliorated defective mitophagy through the PI3K/Akt/eNOS signaling axis, thereby alleviating renal inflammation and fibrosis (Yao et al., 2023)

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