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(A) Patients given a 4-mg dose of nicotine with tablets containing 10 mg or 30 mg of methoxsalen (M10 and M30, respectively) showed higher mean blood nicotine levels and a dramatically reduced urge to smoke compared with patients receiving nicotine and a placebo (P) or 3.5 mg of methoxsalen (M3.5) (B) Similarly, over a 3-h time span, patients receiving the higher doses of the CYP2A6 inhibitor showed an improved ability to maintain their blood nicotine levels

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