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The law stipulates the mandatory inclusion of the percentages of carbon monoxide, in addition to data related to the percentages of tar and nicotine on each package of manufactured tobacco

Additional evidence also supports increases in cardiac inflammation, oxidative stress, and fibrosis after prolonged exposure to electronic cigarettes, which was comparable to damage induced by combustible tobacco products [93]

People usually consume nicotine by using cigarettes and smoke-free products, such as heated tobacco products, e-cigarettes, snus, and nicotine pouches

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Conversely, regular users might prefer larger cartridges for their convenience and extended use

Nevertheless, a significant number of biomarker-based studies, cell/ in vitro and animal studies did indicate that e-cigarette exposure can result in oxidative stress, cellular apoptosis, DNA damage, genotoxicity, and tumor growth (Figure 2, and Supplementary file Materials 2 and 3), all of which can potentially increase risk of developing lung cancer or progression of any cancer