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for example, one study reported the presence of benzaldehyde in e-cigarette aerosol at twice the workplace exposure limit

Furthermore, clinical trials have shown that standard NRT doses are inadequate for rapid metabolizers of nicotine (i.e., those who inactivate nicotine to cotinine and then to 3-hydroxycotinine [3-HC] more quickly than others due to genetic variation affecting the activity of the hepatic enzyme CYP2A6) [20, 25]

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Beginners are advised to start with products containing 5 to 8 mg of nicotine per gram, while regular users typically enjoy products with 20 to 25 mg of nicotine per gram