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Elevated plasma levels may result in a higher incidence and/or severity of ADRs ( Concerning glipizide, it may decrease the renal excretion rate of bupropion which is likely to lead to higher plasma concentrations

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To ensure that the market introduction of a cMRTP benefits the population as a whole, one has to take into account how the product will be used by smoker taking into account non-smokers [9]