After fitting the mixed Gaussian model to cells belonging to the transcriptional state inferred using Monocle that contains the terminal branch and endpoint of the trajectory (Supplementary Fig
Key Findings on Smoking and Sleep Disorders 1
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Studies of this phenomenon have shown that macrophages are activated by factors such as cigarette smoke extracts and release inflammatory mediators such as TNF-, CXCL1, CXCL8, CCL2, leukotriene (LT) B4 and reactive oxygen species (ROS), etc., which mediate the inflammatory response ( Figure 2 Macrophages have different phenotypes with different activation pathways that lead to different organismal responses
Archived from the original on February 23, 2009
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