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These compounds are not unique to nicotine itself but come from the tobacco plants growth and processing environment

Few SLT products had methyl salicylate, pulegone, or ethyl salicylate (1820)

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Neuroimaging studies, show gray-matter abnormalities throughout the brain, in smokers compared to non-smokers, and these are attributed to an upregulation of nicotinic acetylcholine receptors (nAChR) in the prefrontal cortex and the consequent differences in functional connectivity in the prefrontal cortex region in smokers compared to non-smokers (128, 129)

Microbials (mold, yeast, bacteria)