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Symptoms often don't appear until the disease progresses, but they can include: Lack of energy and/or shortness of breath, especially during physical exercise Wheezing, chronic cough and chest tightness Frequent respiratory infections Blue lips or fingernails Coughing up a lot of mucus from the lungs, especially upon waking Swelling in your feet, ankles or legs If you have asthma, you may experience similar symptoms, including wheezing, coughing and shortness of breath