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doi: 10.1152/ajpregu.00407.2011

Glutathione may reduce the production of melanin by inhibiting an enzyme called tyrosinase, which is essential for pigment formation

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The nonenzymatic functions of GSTs involve their interactions with cellular proteins, such as, Jun N-terminal kinase,(JNK), tumor necrosis factor receptor-associated factor-2 (TRAF2), apoptosis-signal-regulating kinase 1 (ASK), serine/threonine kinases (PKA, PKC), and tissue transglutaminase 2 (TGM2), during which, either the interacting protein partner undergoes functional alteration or the GST protein itself is post-translationally modified and/or functionally altered [53], [74]

Some people naturally have more melanin, which may lead to stronger pigmentation or uneven tone

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