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Addiction 115:11411148 Jacob P III, Yu L, Duan M, Ramos L, Yturralde O, Benowitz NL (2011) Determination of the nicotine metabolites cotinine and trans-3-hydroxycotinine in biologic fluids of smokers and non-smokers using liquid chromatographytandem mass spectrometry: biomarkers for tobacco smoke exposure and for phenotyping cytochrome P450 2A6 activity

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Studies carried out with smokers have confirmed these findings in animal models, showing alterations in the respiratory epithelium as an enlargement of the naked epithelium,25 a greater prevalence of hyperplasia and cell atypias26 and ultrastructural cilia abnormalities27