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Over the past years, Prxs have become recognized not only as oxidative stress defense enzymes but also as regulators of phospholipid homeostasis

Furthemore, an increased serotonin metabolism was demonstrated by diminished hypothalamic serotonin levels, lowered 5-hydroxytryptamine (5-HT)/tryptophan ratios and elevated 5-hydroxyindoleacetic acid/5-HT ratios, indicating dysregulated serotonergic system (Jia et al., 2024)

Upon EAE induction, mice develop a relapsing-remitting disease course followed by a phenotypically stable chronic progressive phase [25, 39]

O-GlcNAcylation may serve as a critical mediator between nutritional impairment and brain developmental defects

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