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Ocular signs included epicanthal folds, palpebral ptosis, sunken eyes, infraorbital creases, hypotelorism, hypertelorism/telecanthus, myopia, strabismus, xeropthalmia, and elongated/up-slanting palpebral fissures (Fig

As another indicator of FDAs intentions, the agencys guidance on nonclinical testing of inhaled nicotine drug products provides some insight into the requirements for sponsors seeking to market ENDS as drugs: toxicology testing and submission of information on components of the product, inhalation studies, assessment of product impurities, etc

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& Michaelis, S

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