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While the clinical diagnosis of PD is based on the presence of defining motor features of bradykinesia, rest tremor and rigidity, additional motor symptoms like freezing of gait, postural instability, falls, dysarthria and dysphagia are key drivers of disability in advanced disease [3]

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However, they also pointed out that this explanation is not unarguable due to the fact that EDs are often consumed along with alcohol or used in circumstances inherently associated with increased adrenergic stimulation (e.g., playing sports, excessive work-related physical exertion, or during social gatherings) and these factors may also contribute to AE development [70]