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In addition, hyperinsulinemia leads to a decrease in sex hormone-binding globulin, which can increase the availability of free sex hormones and promote the development of sex hormone-dependent cancers such as breast, prostate, and endometrial cancers (Pinter and Jain, 2017

Thus, alternative chemistries or tank mixes with alternative chemistries may be needed for adequate control

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In addition, if the woman stops smoking, there is the advantage that certain negative effects can be reversed