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Both the MAGI2/GNAI1 SNP rs2714700 and the TENM2 SNP rs1862416 were nominally associated at P 1])

[129] [130] Nicotine has a higher affinity for nicotinic receptors in the brain than those in skeletal muscle, though at toxic doses it can induce contractions and respiratory paralysis

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Symptoms may develop very quickly, over the course of a few days, or more slowly, over months