The carbon monoxide combines with haemoglobin in the red cells, reducing the ability of the blood to carry oxygen O c
And when a smoker takes a puff, the tip of a cigarette can reach over 800 degrees Celsius

This could be assessed based on four factors:[5] Using nicotine upon waking Using nicotine despite being restricted from its use (e.g., banned in certain locations, activities, events) Using nicotine to avoid withdrawal symptoms Waking up in the middle of the night to use nicotine The study concluded that a significant correlation exists between individuals with a nicotine dependence and certain Axis I (e.g., alcohol and drug use disorders, major depression, dysthymia, mania, hypomania, panic disorder with and without agoraphobia, social phobia, specific phobia, and generalized anxiety disorder) and Axis II disorders (e.g., avoidant, dependent, obsessive-compulsive, histrionic, paranoid, schizoid, and antisocial PDs).[6] There was an especially strong association to disorders involving alcohol and other drug use, as well as mood disorders such as major depression, specific phobia, antisocial, and paranoid personality disorders.[7] Nicotine smoking has also been found that put individuals at an increased risk for suicide, biopolar disorder, and a dose-response relationship has been found between smoking and schizophrenia

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Erectile Dysfunction Male sexual function is affected when you smoke
Some studies have suggested that marijuana use, particularly heavy use during adolescence, might affect brain development