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Nicotine is the only gateway substance for which a direct molecular mechanism of cross-sensitization has been experimentally verified in peer-reviewed research, distinguishing it from alcohol and cannabis, whose human gateway effects remain primarily epidemiological

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Sources: JAMA Neurology, Smoking and Risk of Alzheimers Disease JAMA Neurology The Lancet Neurology, Cigarette Smoking and Dementia Risk The Lancet Alzheimers Society, Smoking and Dementia Alzheimers Society Frontiers in Aging Neuroscience, Impact of Smoking on Cognitive Function Frontiers in Aging Neuroscience

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Always Avoid Cigarettes and Secondhand Smoke Cigarette smoke is a leading trigger that makes acute bronchitis worse and can lengthen recovery