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Cigarette advertising dollars also rose slightly, as manufacturers marketed to the captive audience of locked-down, pandemic-stressed viewers, with advertising and promotion expenditures rising from $7.62 billion in 2019 to $7.84 billion in 2020

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Differentially expressed genes (DEGs) were identified using limma for microarrays and DESeq2 for RNAseq data, followed by a meta analysis to identify meta-DEGs