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The production of pro-inflammatory cytokines is also increased in the liver

Chronic smoking also leads to the formation of atheromatous plaques due to increased expression of matrix metalloproteinases (MMP), particularly MMP-12 and MMP-9 in macrophages, MMP-8 and MMP-9 in endothelial cells, and MMP-2 and MMP-9 in vascular smooth muscle cells ( 35 , 36 )

And in North Korea around 45% of men are reported to smoke daily, while almost no women do

This can be a significant advantage, especially for budget-conscious smokers who are looking to save on their smoking expenses

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