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Increased BEN in the limbic system regions (OFC, thalamus, ACC and insula) may indicate that female controls are more irregular in terms of limbic brain functions such as reward, motivation, sensorimotor function

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While nicotine may stimulate specific biochemical pathways, cigarette smoke contains thousands of toxic chemicals that significantly raise the risk of cancer, cardiovascular disease, respiratory illness, and premature mortality

In 2006, a court found several major tobacco companies guilty of misleading the public about the dangers of tobacco products