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RNA-seq and ssGSEA analysis of TCGA cohort and cell lines UMSCC47 (RRID: CVCL_7759) and UDSCC2 cells were harvested after acute exposure to smoke-infused media for 8 h, whereas SCC152 and SCC 154 cells were harvested following chronic smoke-infused media exposure with an additional bolus 8 h prior to isolation

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Histopathologic evidence of tubular damage due to cadmium exposure has been also demonstrated at autopsy or in kidney biopsies in Japanese patients with itai-itai disease (combination of severe renal tubular damage and osteomalacia) [41]

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