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Unfortunately, as with other chemotherapy drugs, many case reports and case series have documented AKI for gemcitabine, primarily TMA, which leads to drug-induced and dose-dependent thrombotic microangiopathy (DITMA) through immuno- and toxicity-mediated mechanisms

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Water-soluble organosulfur compounds like SAC and its metabolite, N-acetyl-S-allyl-L-cysteine, may be used as reliable markers of compliance in clinical trials involving garlic intake (6, 18)

Its thiol group scavenges reactive oxygen species (ROS), regenerates antioxidant enzymes, and forms redox-sensitive disulfides that sense oxidative stress [36]

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