Chronic stress, elevated glucocorticoid exposure, and neuroinflammatory signaling suppress the proliferation, differentiation, and survival of neural progenitor cells, leading to reduced hippocampal volume and functional impairments commonly observed in major depressive disorder (42)
10.1165/rcmb.2023-0038OC [DOI] [PMC free article] [PubMed] [Google Scholar] Yanqing L., Zhang C., Cheng H., Lv L., Zhu X., Ma M., et al
Furthermore, the Keap1/NRF2/ARE signaling pathway plays a critical role in tumor cell drug resistance, and PVT1 may further promote the development of resistance by regulating this pathway [169]
Rossignol and Frye, 2012)
They also have a role in several disorders
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