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High-performance liquid chromatography was conducted using an Agilent 1200 RR with an Agilent 6410 Triple Quad mass detector as described previously 19

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The two regularly updated studies on the global death toll from tobacco use published respectively by the World Health Organization and the Institute for Health Metrics and Evaluation agree that around 8 million people die prematurely every year from tobacco use

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Active and passive smoking also causes increased risk of miscarriage during pregnancy, which is potentiated by the amount of cigarettes smoked per day [12]