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Extracts from tobacco rods were serially diluted and superfused over HEK293T cells expressing the human TRPM8 cold/menthol receptor activated by menthol, WS-3 and other synthetic cooling agents, measuring activity by Calcium-microfluorimetry as published (Supplementary file) 3

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nicotine salt vs free-base), and 66% of brands did not disclose information on nicotine type (i.e

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