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They speculate that the poorer performance of e-cigs across all studies when pooled may mirror the changing situation of nicotine replacement therapy: Data from the large population-based California Tobacco Surveys, showed that nicotine replacement therapy (NRT) was associated with long-term success in quitting cigarettes when available by prescription only, but this association was lost when NRT became available over-the-counter

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Several other combinations are particularly worth knowing about because of how frequently they appear in clinical and emergency settings

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