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Likewise, in murine macrophages, the activated 7nAChR can mediate Jak2-STAT3 activation and then can induce the phosphorylation of STAT3, which subsequently downregulates pro-inflammatory cytokines (e.g., IL6, IL12, and TNF-) [133]

Compared to the non-smokers with asthma, the smokers with asthma had significantly impaired lung function, as shown by (i) lower forced expiration volume of 1s% (FEV 1 %), a ratio of FEV 1 /FVC, and asthma control test (ACT) scores, and (ii) higher asthma control questionnaire (ACQ) scores

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After all, I'm cured, four months in rehab, clean as Ivory Snow, sitting with white powder that can't hurt me any more

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