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federal government agencies, have demonstrated that using reduced nicotine content tobacco cigarettes like VLN helps smokers reduce their nicotine exposure and dependence, smoke fewer cigarettes per day, increase their number of smoke-free days, and double their quit attempts all with minimal or no nicotine withdrawal symptoms or compensatory smoking behavior

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Among the studies that do analyze doseresponse relationships, there is large variation in the units and dose categories used in reporting their findings (for example, the use of pack-years or cigarettes per day) 24,25 , which complicates the comparability and consolidation of evidence