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So a framework for a risk continuum for tobacco and nicotine products can be constructed based on epidemiological and clinical data, and other scientific studies, that position cigarettes at the high risk end, nicotine replacement therapy at the low risk end, and smokeless tobacco products, because their principal route of exposure leads to little risk of respiratory diseases caused by smoking, between the two but much closer to nicotine replacement therapy than cigarettes

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Circ Res 2000;86:E3641

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Extensive research has shown that smoking not only increases the risk of developing type 2 diabetes but also exacerbates the complications associated with the condition

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