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Curr Opin Plant Biol 35:3744

Despite its widespread popularity, some scientists began warning against the harmful effects of nicotine in the leaves as early as the 17th century

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[45] Potential for Indigenous American opposition [edit] As some traditions and ceremonies of a number of cultures and ethnicities of Native Americans in the United States and First Nations in North America have been based on tobacco since pre-Columbian times, some potential for unintended abrogation of such traditions may exist from authorities seeking to eliminate tobacco from worldwide use traditions of non -combustive use of tobacco for some forms of indigenous American ceremonial purposes have begun to be used for cessation of cigarette use among indigenous tribal members, [46] while members of the Oglala Lakota have had their struggles to retain important historic tribal artifacts used for tobacco's traditional role in their ethnicity's traditions, to prevent their illegal sale

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