Blood was collected at necropsy and processed to serum, which was analyzed using a LC/MS/MS method
G.SealeP.FurmanD
Clinical, pharmacokinetic and pharmacodynamic findings from a phase 1 clinical trial of an Eg5 inhibitor (AZD4877) in patients with refractory acute myeloid leukemia, poster presentation
When this balance is disrupted, leading to elevated levels of uric acid in the blood, hyperuricemia occurs (2,3)
The schedule skips missed doses instead of doubling the next injection
The conditions of real-time PCR were as follows: (1) initial PCR activation 95 C, 10 min, (2) 3-step cycling for 35 cycles involving (a) denaturation 95 C, 30 s, (b) annealing 58 C, 1 min and (c) extension 72 C, 1 min, followed by a dissociation phase