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This arrest is mediated by downregulation of enzymes and signaling molecules such as tyrosine cyclooxygenase, ornithine decarboxylase and multiple kinases, thus impeding neoplastic proliferation (60)

The bulk mass of the cornea is attributed to the extracellular matrix of the stroma, primarily composed of collagen types I and V and the proteoglycans keratocan, decorin, lumican, and mimecan, which are important in limiting the collagen fibril diameter and maintaining tissue transparency [37]

10.1038/s41592-022-01523-1

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Fu X, He Y, Wang X, Peng D, Chen X, Li X, et al

Fouquerel E, Lormand J, Bose A, Lee H-T, Kim GS, Li J, Sobol RW, Freudenthal BD, Myong S, Opresko PL (2016) Oxidative guanine base damage regulates human telomerase activity