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INH is a prodrug that enters the Mtb cytoplasm via passive diffusion, where it inhibits mycolic acid synthesis by targeting the InhA enzyme, an essential catalyst in an early step of the mycolic acid biosynthetic pathway (Mitchison, 1956)

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Sheldons twin sister, Missy, sometimes resents all the attention Sheldon gets, but also remains the one person who can reliably tell Sheldon the truth

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Pathogens and host immunity in the ancient human oral cavity