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Methods Five e-cigarettes with different e-liquid formulations containing 1.6 % and 2.4 % nicotine and a conventional tobacco cigarette were randomized among 24 subjects under two exposure sessions consisting of a 30-min controlled and a one-hour ad lib use period to assess plasma nicotine levels, impacts on smoking urge and adverse events

Participants who quit smoking had significantly greater reductions in V S /f P across regions than non-quitters, and correlations were found between reductions in cigarettes per day and decreases in V S /f P for brainstem and cerebellum, but there was no between-group effect of treatment type