A deficiency of H6PDH therefore leads to an impairment of HSD11B1 reductive function and apparent cortisone reductase deficiency [238]
By controlling antioxidant genes through the FoxO3a/proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1) complex, SIRT1 prevents the generation of superoxide (Wang et al
51:19 (2024) Kobayashi J, Sasaki D, Hara KY, Hasunuma T, Kondo A
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Nat Commun 14 , 828 (2023)
97 Hyperoxia injury during lung development upregulates the expression of Wnt2b, Wnt5a, Wnt9a, and Wnt16, leading to excessive activation of Wnt/-catenin in fibroblasts and AT2 cells, characterized by the accumulation of -catenin and an increase in AXIN2 expression
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