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In a previous clinical study, the Achilles tendons of patients with rheumatoid arthritis who received dexamethasone treatment for at least 3 months had a low density of collagen type 1 ( In vitro analyses have shown that dexamethasone treatment reduces the gene expression of collagen type 1, collagen synthesis, and proliferation of tenocytes (Wong et al., 2003
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Chen S, Emery SE, Pei M: Coculture of synovium-derived stem cells and nucleus pulposus cells in serum-free defined medium with supplementation of transforming growth factor-beta1: a potential application of tissue-specific stem cells in disc regeneration