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Earlier work in psychosis risk largely focused on single substances, whereas our approach captures the real-world scenario where many young people use tobacco and cannabis together

Selective migration to western countries may also contribute to a higher prevalence of psychosis

While positive symptoms can often be effectively improved with available antipsychotic medications, current treatment options for negative symptoms are relatively limited in effectiveness, and they remain an unmet medical need 7

it may be (and Gurillo and colleagues discuss the biological plausibility of nicotine in this context), but that will need to be tested

They included studies that used ICD or DSM criteria for psychotic disorders (including schizophrenia, schizophreniform disorder, schizoaffective disorder, delusional disorder, non-affective psychotic disorder, atypical psychosis, psychotic depression, and bipolar mania with psychotic features)