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Specifically, different allelic variations in CYP2D6 influence enzyme activity leading to either ultra-metabolizers or poor-metabolizers of CYP2D6 substrates (175, 176)

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"In just the third year in the league he already held the career record in home runs (137) and went on to break his own record 577 more times." The gap between Ruth and the second-place finisher was even wider than the year before, when Ruth hit 54 homers to George Sisler's 35

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