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In a disease state, it may not be possible to identify these inherent inter-individual differences and this may confound attempts to identify the effects due to disease

But normal post-extraction pain follows a predictable downward curve

Decreased taste sensitivity: Smoking can diminish the ability to taste different flavors due to damage to the taste buds

2014, titled Long-term effects of cannabis on brain structure, has found reduced gray matter density in long-term cannabis users, which is linked to impaired cognitive function, including memory deficits

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