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Also, the treatment of DC separated from CD and UC with cigarette smoke extract (CSE) upregulated MHC-II and costimulatory molecules and downregulated the expression of CXCL10 and CCL3 in UC than CD

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A century later, tobaccolargely produced through the labor of enslaved people and, later, sharecropperscontinued to help fuel the nations economy during and after the Civil War, which placed states like Tennessee, Kentucky, Virginia, and the Carolinas (plus others with similar temperate climates) at the epicenter of the global tobacco trade

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