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These included smoke exposure biomarker genes like cyclin-dependent kinase inhibitor 1A (CDKN1A) and cytochrome P-450 s (e.g., CYP1A1 involved in polycyclic aromatic hydrocarbon bioactivation)

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Effective TB control must therefore couple biomedical interventionssystematic Latent Tuberculosis Infection (LTBI) screening of recent migrants, integrated TBHIV services, smoke-free housing initiativeswith policies that tackle the underlying social determinants of health, such as overcrowding, insecure employment, and inadequate access to care (Zumla et al., 2025

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