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August 12, 2014 Sure smoking isn't good for your lungs or your heart

The letter went so far as to claim that the paucity of evidence of serious harm to e-cigarette users since they were first marketed in 2006, with millions sold, was proof in itself.[xxxii] We are here obliged to recall the aphorism, often attributed to astrophysicists Martin Rees or Carl Sagan, that "absence of evidence is not evidence of absence".[xxxiii] Absence of evidence is not evidence of absence

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Nature 578, 8293 (2020)

if it becomes excessively hot, it directly irritates your throat and lungs, which then triggers an involuntary cough