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The VDRA mRNA represents the predominant transcript from the VDR gene and this mRNA encodes two protein isoforms that are the result of the use of alternative in-frame translation stop codons

Dosing Protocol A suggested daily titration approach based on common reference doses and animal-to-human extrapolation

Second, the role of metabolic reprogramming in ferroptosis highlights how sustained mechanical stress and inflammation reshape lipid, amino acid, iron, and glucose metabolic pathways in OA chondrocytes and synovial cells

Science (1996) 3

168 Regulation [EC] 396/2005 (2022)

Therefore, in normal tissues, p53 tends to positively regulate ferroptosis, whereas mutant p53 makes tumor cells more sensitive to ferroptosis