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This suggests that the anti-epileptic effect of GAS may also be attributed to regulating MAPK-related inflammatory responses

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Multiple Sclerosis is a classic example of autoimmune demyelination in the CNS (Kuhlmann et al., 2008)

These are not minor caveats they are the central limitation of the current evidence

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Seizure disorders: Compounds affecting neuroplasticity and excitability theoretically warrant caution in seizure-prone individuals