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500 The study revealed that patients receiving a single intravenous dose of ustekinumab (130 mg or 6 mg/kg) followed by a maintenance dose of 90 mg subcutaneously every 8 weeks experienced a significant reduction in symptoms such as rectal bleeding and no significant adverse events

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Acetaldehyde is then oxidized by acetaldehyde dehydrogenases (ALDH2, ALDH1B1 and ALDH1A1) to acetate