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Amplified IGF-1/IGF-1R signaling has been associated with increased relative risk for development of colorectal cancer (CRC) as well as CRC metastasis, and resistance to chemotherapeutic drugs (Weber et al., 2002

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In particular, directed cycles may impose unintended equalities, missing shortcut arcs may prevent the graph representation from satisfying explicit inference closure, and redundant arcs may enlarge the RMP without further contracting the dual region

J Transl Med 13:103