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However, overexpression of myo-inositol oxygenase (MIOX) can aggravate cisplatin-induced ferroptosis in the context of AKI by downregulating GPX4 activity, promoting lipid peroxidation and increasing the ferritinophagy rate [172]

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Lastly, additional genetic manipulations should be performed such as restoring the deleted GDH genes or overexpression GDH genes in the knockout mutants