Endocrinology 124 , 4048 (1989)
While formal clinical guidelines await development, evidence-based principles can guide initial exploration
Landmark 2017 Cell paper One of the foundational studies (by Baar et al.) was titled Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging. This work demonstrated: In mice that were aged or given chemotherapy (accelerated ageing), treatment with FOXO4-DRI improved physical performance, fur quality, and renal function
Diabetic retinopathy damages retinal and choroidal vessels
however, antibiotics, particularly fluoroquinolones, can promote spore conversion to the active trophic form, which can ultimately induce CDAD (Ppin et al., 2005)
M., von Gise, A., Zhou, P., Hu, T., He, L., Wu, K