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Cytotoxic payloads, integral to BsADCs, play a crucial role in determining the overall antitumor effect and potential adverse reactions

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The PDE6 mutation in the rd10 retinal degeneration mouse model causes protein mislocalization and instability and promotes cell death through increased ion influx

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Gasperini et al., 2013

A small fraction of urobilinogen is reabsorbed into the enterohepatic circulation and is either re-excreted by the liver or eliminated through the kidneys [42]