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Nauman G, Gray JC, Parkinson R et al (2018) Systematic review of intravenous ascorbate in cancer clinical trials

According to the proposed mechanism, Gln consumption by ccRCC tumor cells leads to local depletion of extracellular matrix Gln, thereby activating the HIF1/IL-23 signaling pathway in tumor-infiltrating macrophages

This change may be associated with the depletion of carbohydrate reserves that occur during fasting 62